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Check Out This Revolutionary Next Generation Treatment for Depression

Depression affects 8% to 10% of people in America every year. Over the years, physicians and scientists alike have been continuously finding ways to treat depression. Depression is a serious mental health illness, which is curable with proper medication, counseling, and exercise.

Since 1987, the medical field found a new drug that could treat depression. Back in that time, it was a groundbreaking invention after so many rigorous years of experiment in finding the right treatment. Prozac was introduced. It is a very effective antidepressant medication that has fewer effects on the patient compared to the medications formerly used.

Prozac is a Selective Serotonin Reuptake Inhibitors or SSRI.  But four years later, another anti-depression medication came out. Zoloft was available in the market in 1991, followed by Paxil a year later. Both medications are favorable choices of doctors as they are safer than previous medications because they have fewer side effects.

But in the dawn of 2019, a revolutionary treatment for depression came into existence – Spravato. Spravato is an esketamine nasal spray that is known to be a very effective antidepressant treatment. The Food and Drug Administration (FDA) has approved this treatment on March 5, 2019. If the claims are true, this is the first-ever true medication for major depression after so many decades of research. It is an antidepressant treatment-resistant depression medication.

What is Spravato?

Spravato is the newest treatment for resistant depression. The drug is made from ketamine. Spravato is a nasal spray that is used along with an oral antidepressant treatment-resistant depression medication for adults. The drug takes effect within 24 hours after its administration.

How Does Spravato Work?

Spravato is made using ketamine, a drug used anesthetics.  However, doctors at the Yale School of Medicine discovered that the drug ketamine. The drug is known for its usage in surgery as anesthesia triggers glutamate production. GABA and glutamate are known for playing a major role in schizophrenia and seizure disorders.

These two neurotransmitters work together to form a compounded push and pull responses, making the brain’s electrical activity spark and stop. According to the researchers, they believe that these two are responsible for brain major activity, including mood. In addition, extreme stress and depression alter the glutamate in signaling the brain. The effects are on the neurons and they become less adaptable, making it difficult to communicate with other neurons.

How was Spravato Discovered?

The Yale Research Laboratory showed that the use of ketamine as anesthesia boosts and triggers glutamate production in which a stream flowing of event cues the brain to create a neural connection. This will make the brain create a new pathway, making it more adaptable. In this way, patients are given the chance to develop more positive thoughts and actions.

The neuroscience research team found a gleam of hope from this drug when they saw an increase of clinical evidence in people suffering from treatment-resistant depression who showed improvement. Clinical trial suggests that Spravato (ketamine) should be a part of a comprehensive treatment. Meaning, it must go along with oral antidepressant medication to help facilitate a neutral pathway creation. In this way, the patient stays safe from a relapse of depression.

Cautions and Reminders

Though Spravato is quite effective and has a superior effect in both anesthetics and in aiding depression. It still does have some unpleasant yet bearable side effects. These side effects can occur either during and after taking the drug. Its side effects include dizziness, an increase in blood pressure, disassociation, nausea, sedation. Few people also experience a spinning sensation, anxiety, lack of energy, vomiting and feeling drunk. Patients are asked to have a companion during and after the administration. Nevertheless, these side effects are all temporary.

The revolutionary discovery of this drug is groundbreaking in the state of the art of technology. This has given a new streak of hope for patients battling with life long depression. Nevertheless, one should keep in mind that medication alone without the will of the patient will not cure depression. Doctors often advise that the use of ketamine as an antidepressant medication is most effective when the patient undergoes cognitive behavioral therapy. In this way, with the effect of ketamine on the brain’s psychotherapy, the patient learns productive attitudes and behavior.  Depression is a serious condition but is treatable with the right therapy and medication.

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